The idea of an Intelligent Digital Avatar conjures up many images from a complete virtual world that one can safely define, develop and play in to rogue robots running amok and destroying mankind. The reality is much less dramatic but no less far reaching and exciting. This talk will discuss Digital Twins and chart their history to present day technological capability along with the challenges we face to realise the potential of Digital Twins. Professor Mark Girolami’s research lies at the intersection of the Statistical, Mathematical, and Computing Sciences, where he has made major contributions to the development of Machine Learning and applications in the Engineering and Natural Sciences.